Cytokines in the Genesis and Treatment of Cancer

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Contenidos del Libro:

I.- INFECTIOUS AGENTS, CYTOKINES, AND CANCER

1.- Helicobacter pylori and Cytokines in the Genesis of Gastric Cancer
2.- HTLV-1, Cytokines, and Cancer
3.- Herpesviruses, Cytokines, and Cancer

II.- CYTOKINES AND CARCINOGENESIS

4.- Tumor Necrosis Factor and Cancer
5.- Transforming Growth Factor-β and Cancer
6.- Interleukin-1 Family of Cytokines and Cancer
7.- Interleukin-4/13 and Cancer
8.- Interleukin-6 and Castleman’s Disease
9.- Interleukin-10 (IL-10): Biology, Immune Regulation, and Cancer
10.- Cytokines in Multiple Myeloma: Therapeutic Implications
11.- In Vivo Murine Cytokine Models and the Genesis of Cancer
12.- Experimental Models of Cytokines and Cancer Prevention

III.- CYTOKINES AND TUMOR STROMA/METASTASIS

13.- Cytokines in the Tumor Stroma

14.- Cytokines and Tumor Angiogenesis

15.- Chemokine and Receptor Expression in Tumor Progression

16.- The Biology of Cancer Cachexia and the Role of TNF-α

IV.- CYTOKINES IN THE TREATMENT OF CANCER

17.- Interleukin-2 and Cancer Therapy

18.- Interleukin-12 and Cancer Therapy

19.- The Type I Interferon System With Emphasis on Its Role in Malignancies: Interferons Are More Than “Antivirals”

20.- Combination Cytokine Therapy

21.- Novel Strategies for Cytokine Administration Via Targeting

22.- Cytokines and Cancer Vaccines

23.- Anticytokine Therapy

24.- Cytokines in the Supportive Care of Cancer

Cytokines in Human Health

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Contenidos del Libro:

1. Introduction to Cytokines as Targets for Immunomodulation
2. Cytokine Measurement Tools for Immunotoxicology
3. The Relevance of the T1/T2 Paradigm in Immunotoxicology: Example of Drug Hypersensitivity Reactions
4. Microbial Exploitation and Subversion of the Human Chemokine Network
5. The Use of Cytokines in the Identification and Characterization of Chemical Allergens
6. Inflammatory Cytokines and Lung Toxicity
7. Cytokine Polymorphisms and Relationship to Disease
8. Effects of Drugs of Abuse on Cytokine Responses
9. Preclinical Approaches for the Safety Assessment of Cytokines
10. Flu-Like Syndrome and Cytokines
11. Cytokine-Induced Vascular Leak Syndrome
12. Cytokines and Autoimmune Diseases: From the Control of Autoimmune Diseases With Anti-Cytokine Treatment to the Induction of Autoimmunity With Cytokine Treatment
13. Evaluation of Antibodies in Clinical Trials of Cytokines
14. Cytokines and Pharmacokinetic Drug Interactions
15. Evaluation of the Immunological Effects of Cytokines Administered to Patients With Cancer
16. Clinical Adverse Effects of Cytokines on the Immune System 

Actualización: 23/08/2012

Cytokines and Chemokines in Infectious Diseases Handbook

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Contenidos del Libro:

1. Cytokines in Infectious Diseases
   
2. Cytokines in Gram-Negative Infections
   
3. Cytokines in Gram-Positive Infection
   
4. Cytokines in Mycobacterial Infections
   
5. Cytokines in Other Bacterial Infections
   
6. Cytokines in Fungal Infections
   
7. Cytokines in Parasitic Infections
   
8. Cytokines in Viral Infections
   
9. Cytokines as Therapeutic Agents in Infectious Diseases
   
10. Anticytokine-Based Therapy in Treatment of Infectious Diseases

Cytokine Protocols

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Contenidos del Libro:

1. Large-Scale Generation of Plasmids that Express Type I Interferon
2. Identification of trans-Acting Factors by Electrophoretic Mobility Shift Assay
3. Modulation of the Interferon-γ Signal by Transfection of Cells with an Antisense-RNA Expressing Vector
4. Competitive RT-PCR to Quantify Small Amounts of mRNA
5. In Situ Hybridization for Cytokines in Human Tissue Biopsies
6. Purification, Identification, and Synthesis of Chemokines
7. Receptor Isolation and Characterization
8. Crystallization of Cytokine–Receptor Complexes
9. Biosensor Analysis of Receptor–Ligand Interactions
10. Analysis of SH2 Ligands and Identification of Sites of Interaction
11. Assays for Antiviral Activity
12. Assays for Cytotoxicity
13. Assays for Chemotaxis
14. In Vitro and In Vivo Assays for High-Molecular-Weight Pegylated Muteins of Granulocyte Colony-Stimulating Factor
15. Development of a Mammalian Tet-On Expression Cell Line
16. Immunohistochemical Detection of Cytokines in Human Tissue Sections
17. Detection of Cytokine- and Chemokine-Expressing Cells at the Single Cell Level
18. Detection of Cytokine Signal Transduction “Cross-Talk” in Leukocyte Activation
19. Assay System for the Effect of Prostaglandin E2 in the Determination of Polarized Cytokine Production

Actualización: 23/08/2012

Mucosal Immunology and Virology

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Contenidos del Libro:

1. The Role of Mucosal Immunity in Protection against Viral Diseases
   
2. Anogenital Mucosal Immunology and Virology
   
3. Gastrointestinal Mucosal Immunology
   
4. Virology of the Gastrointestinal Tract
   
5. Oral manifestations of Viral Diseases
   
6. Common Respiratory Viruses and Pulmonary Mucosal Immunology
   
7. Ophthalmic Manifestations of Viral Diseases

Viral Pathogenesis and Immunity

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Contenidos del Libro:

Part I: Essentials of Viral Pathogenesis

1.- Historical Roots

2.- The Sequential Steps in Viral Infection

3.- Cellular Receptors and Viral Tropism

4.- Virus–Cell Interactions

Part II: Host Responses to Viral Infection

5.- Innate Immunity

6.- Immune Responses to Viral Infection

7.- Virus-Induced Immunopathology

8.- Virus-Induced Immunosuppression

Part III: Virus–Host Interactions

9.- Viral Virulence

10.- Viral Persistence

11.- Viral Oncogenesis: Retroviruses

12.- Viral Oncogenesis: DNA Viruses

13.- Host Susceptibility to Viral Diseases

14.- HIV, SIV and the Pathogenesis of AIDS

Part IV: Ecology and Control of Viral Infections

15.- Emerging Viral Diseases

16.- Antiviral Therapy

17.- Viral Vaccines

Microbial DNA and Host Immunity

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Contenidos del Libro:

PART I: INTRODUCTION

1.- Immunostimulatory DNA: An Overview

2.- Historical Perspectives

PART II: RECEPTORS AND SIGNALING

3.- Signal Transduction Pathways Activated By CpG-DNA

4.- A Novel Toll-Like Receptor that Recognizes Bacterial DNA

5.- Activation of Innate Immunity by Microbial Nucleic Acids

6.- Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG

PART III: CELL ACTIVATION

7.- Activation of NK Cell By Immunostimulatory Oligo-DNA in Mouse and Human

8.- Regulation of Antigen Presenting Cell Function by CpG DNA

9 .-Activation of B Cells by CpG Motifs in Bacterial DNA

10.- IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells

11.- Cross-Priming of CD8+ T Cells by Immunostimulatory Sequence DNA

PART IV: VACCINATION STRATEGIES

12.- The Th1 Adjuvant Effect of Immunostimulatory (ISS) DNA Sequences

13.- Immunostimulatory DNA Prepriming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses

14.- Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen

15.- Immunostimulatory DNA Sequence-Based Mucosal Vaccines

16.- Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence by Liposomal Delivery

17.- Immunostimulatory Sequences in Plasmid Vectors

PART V: APPLICATIONS—INFECTIOUS DISEASE

18.- Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B

19.- Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine?

20.- Immunoprotective Activity of CpG Oligonucleotides

21.- Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection

PART VI: APPLICATIONS—ALLERGY

22.- DNA-Based Immunotherapeutics For Allergic Disease

24.- CpG Oligodeoxynucleotides in Asthma

25.- Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides

PART VII: APPLICATIONS—CANCER

26.- CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma

PART VIII: INFLAMMATION AND AUTOIMMUNITY

27.- The Antigenicity of Bacterial DNA

28.- Inflammatogenic Properties of Immunostimulatory DNA Sequences

29.- The Role of Immunostimulatory DNA Sequences in Arthritis

30.- Effects of Immunostimulatory DNA Oligonucleotides on Experimental Colitis

PART IX: SAFETY CONSIDERATIONS

31.- CpG ODN—Safety Considerations

Mobile Genetic Elements

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Contenidos del Libro:

1. Mobile Genetic Elements as Natural Tools for Genome Evolution 
2. Detection of Transposable Elements in Drosophila Salivary Gland Polytene Chromosomes by In Situ Hybridization
3. Fluorescent In Situ Hybridization With Transposable Element Probes to Mitotic Chromosomal Heterochromatin of Drosophila
4. Southern Blot Analysis of Individual Drosophila Flies
5. Computational Analysis of Transposable Element Sequences
6. Biochemical Analysis of Long Terminal Repeat Retrotransposons
7. Tn5 as a Molecular Genetics Tool
8. Gene Targeting in Drosophila
9. TE-Based Mutagenesis Systems in Plants
10. The Use of Double-Stranded RNA to Knock Down Specific Gene Activity
11. The Application of LTR Retrotransposons as Molecular Markers in Plants
12. MITE Display
13. Retroposon Mapping in Molecular Systematics
14. Transformation Systems in Insects
15. Transposable Elements for Transgenesis and Insertional Mutagenesis in Vertebrates

 Actualización: 17/08/2012

Transgenic Plants

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Contenidos del Libro:

PART I. INTRODUCTION

1. Transgenic Plants: An Historical Perspective

PART II. TRANSFORMATION

2. Plant Transformation: Agrobacterium-Mediated Gene Transfer

3. Production of Hairy Root Cultures and Transgenic Plants by Agrobacterium rhizogenes-Mediated Transformation

4. Stable Transformation of Plant Cells by Particle Bombardment/Biolistics

5. Electroporation: Introduction and Expression of Transgenes in Plant Protoplasts

6. Floral Dip: Agrobacterium-Mediated Germ Line Transformation

7. Production of Transgenic Crops by the Floral-Dip Method

8. Chloroplast Genetic Engineering to Improve Agronomic Traits

PART III. REGENERATION

9. Organogenesis From Transformed Tomato Explants

10. Genetic Transformation of Conifers Utilizing Somatic Embryogenesis

11. Regeneration of Transgenic Cassava From Transformed Embryogenic Tissues

12. Genetic Transformation of Mature Citrus Plants

PART IV. SELECTION

13. Selectable Markers: Antibiotic and Herbicide Resistance

14. Histochemical and Fluorometric Assays foruidA (GUS) Gene Detection

15. Green Fluorescent Protein Quantification in Whole Plants

16. Positive Selection

17. Elimination of Marker Genes From Transgenic Plants Using MAT Vector Systems

18. Simple and Efficient Removal of Marker Genes From Plastids by Homologous Recombination

PART V. TRANSGENE INTEGRATION, EXPRESSION, AND LOCALIZATION

19. The Study of Transgene Copy Number and Organization

20. Analysis of Gene Expression in Transgenic Plants

21. Transgene Integration: Use of Matrix Attachment Regions

22. Fluorescence In Situ Hybridization to Localize Transgenes in Plant Chromosomes

23. Amplification of Genomic Sequences Flanking T-DNA Insertions by Thermal Asymmetric Interlaced Polymerase Chain Reaction

PART VI. RISK ASSESSMENT

24. Agrobacterium Persistence in Plant Tissues After Transformation

25. Transgene Dispersal Through Pollen

PART VII. TRANSGENIC CROPS

26. Transgenic Crops: The Current and Next Generations

27. Comparative Development and Impact of Transgenic Papayas in Hawaii, Jamaica, and Venezuela.


Actualización: 23/08/2012